Human Recombinant CD137 from HEK293 cells VWR


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We then investigated the potential role of NF-κB signaling in regulating CD137 expression. Description: Human CD137 ELISA Kit. Reactivity: Human. Sample type: Cell culture supernatant, Serum, Cell culture extracts, Hep Plasma, EDTA Plasma, Cit plasma. Compare (max 4) (7) Recombinant. CD137 Imported

Information which has been imported from another database using automatic procedures.


Automatic assertion inferred from database entries i CD137, also known as 4-1BB or ILA (for Induced by Lymphocyte Activation) is a 39kDa type I integral membrane protein of the TNF/NGF family.

CD137 is expressed by activated T cells, dendritic cells, NK cells, granulocytes  av A Karlsson-Parra — ligand as additional intratumoral immune priming approach.


With high purity, high biological activity, high stability, and other superior features, you can use this Human CD137 protein for relevant bioassay and related research. CD137 is expressed on activated T cells, B cells, monocytes, and follicular dendritic cells.

CD137 - CD137 -

Aktivering av tumörspecifika T-celler leder till ett immunmedierat  AGEN2373 är en monoklonal antikropp riktad mot CD137 (4-1BB) och väntas gå över i klinisk fas i mitten av nästa år, vilket är samma  Missa Maria Magdalena för soli, kör, två orglar och blåsorkester (nosag CD 137) (text: ur Bibeln); Motetti obligati (text: ur Bibeln); Cla-ma-vi för fyra körer (olika  Adress.

Patent number: 10689454. Abstract: The present invention relates to antibodies (and fragments, variants, fusions and  Intratumoral administration of pro-inflammatory allogeneic, "off-the-shelf", dendritic cells in combination with anti-PD-1 or anti-CD137 has a  A Geno Technology, Inc. (USA) brand name. Safety Data Sheet. Cat. # BAN2116. 4-1BB/TNFRSF9/CD137.
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CD137 helps regulate the activation of many immune cells, including CD4(+) T cells, CD8(+) T cells, dendritic cells, and natural killer cells. CD137 is a 39 kD transmembrane protein also known as 4-1BB. It is expressed on activated T cells. CD137 is a type I membrane protein and a member of the tumor necrosis factor receptor superfamily. CD137 appears to be important for T cell proliferation and survival, and induces monocyte activation through its interaction with 4-1BB ligand. REVIEW CD137 and CD137L signals are main drivers of type 1, cell-mediated immune responses Bhushan Dharmadhikari a, Meihui Wu , Nur Sharalyn Abdullah a, Sakthi Rajendran , Nur Diana Ishak , Emily Nickles , Zulkarnain Harfuddin a, b, and Herbert Schwarz, aDepartment of Physiology, and Immunology Programme, National University of Singapore, Singapore; bNUS Graduate School for Integrative Sciences CD137 agonistic activity, their clinical use is limited to can-cer patients who highly express the antigen. This is in sharp contrast to anti–PD-1/PD-L1 antibody and anti-CTLA4 antibody, which can be used for patients without consid-ering the expression of specific tumor-associated antigen.

In conclusion, activation of CD137 signaling promoted sprouting angiogenesis by increased VEGFA secretion and the VEGFR2/Akt/eNOS pathway. These findings   Human CD137 (4-1BB) is expressed on activated T cells within 24-48 hours of activation (3). CD137 is a type I membrane protein and a member of the tumor  CD137, also known as 4-1BB, is a TNFR family member that is expressed on activated T cells, NK cells and a number of other activated cells of hematopoietic   Human CD137 (4-1BB), FC Fusion (ILA ); Human secreted CD137, Fc fusion protein, also known as Tumor Necrosis Factor Receptor Superfamily member 9,  24 Mar 2020 CD137 (also known as 4-1BB and TNFRSF9) and its ligand,. CD137L (also called 4-1BBL or TNFSF9), are expressed on a variety of  Although CD137 has been cloned from activated T cells in mouse and man [3, 4], its expression has been detected subse- quently on NK cells, monocytes, DCs, B   15 Apr 2020 CD137 is expressed on a subset of FOXP3+ regulatory CD4 T cells (Tregs), and CD137+ Tregs are the main source of soluble CD137. Soluble  CD137, a member of the tumor necrosis factor receptor superfamily, represents a promising target for enhancing antitumor immune responses (1). The functions  T1 - Expression of CD137 (4-1BB) on Human Follicular Dendritic Cells.
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Anti-CD137 mAb is currently undergoing phase I and II clinical trials for cancer [28]. In preclinical models, immunotherapeutic doses of CD137-speciWc mAb have not shown serious deleterious eVects. Described toxic eVects include myelosuppression [33] mediated by cytokines released in the bone marrow microenvironment. CD137 is a costimulatory member of the TNF receptor superfamily that is expressed on a variety of immune cells following activation, including T cells, dendritic cells, and natural killer cells. Signaling via CD137 can lead to cytokine induction, prevention of activation-induced cell death, and CD137 ligand signaling induces human monocyte to dendritic cell differentiation Shaqireen Kwajah M. M. and Herbert Schwarz Department of Physiology and Immunology Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore The ligand for CD137 (4-1BB) is expressed on peripheral human monocytes and delivers a CD137 tumor necrosis factor receptor superfamily member 9, Doxy doxycycline, MAPK mitogen-activated protein kinase, siCTL control siRNA, siMAPK1 siRNA against MAPK1, PCR polymerase chain reaction. We then investigated the potential role of NF-κB signaling in regulating CD137 expression.

It is encoded by TNFRSF9 (tumor necrosis factor receptor superfamily,  CD137 (4-1BB) is expressed on activated CD4+ and CD8+ T cells, activated B cells, and natural killer cells, and can also be found on resting monocytes and  Cited in 4 publications. View Human 4-1BB/TNFRSF9/CD137 Antibody (AF838) validated in Human. CD137 (4–1BB) was originally identified as a molecule expressed on activated mouse and human CD8+ and CD4+ T cells. It is a member of the TNFR family and  CD137 Antibody (BBK-2) is a monoclonal anti-CD137 antibody that detects human CD137 by WB, IP, IF and FCM. The 3H3 monoclonal antibody reacts with mouse 4-1BB, a TNF receptor superfamily member also known as CD137.
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All Fabs bound efficiently to CD137 + cells ( Supplementary Figure 3 ). No binding was observed to CD137 − L-428-control cells (not shown). 137A and 137C showed weaker binding affinity than the other Fabs, making them suitable for the generation of the bispecific antibody. CD137 Antibody (BBK-2) is a monoclonal anti-CD137 antibody that detects human CD137 by WB, IP, IF and FCM. CD137 (4-1BB, TNFRSF9) is increasingly recognized as a pow-erful inducer of antitumor immune responses. The potency of CD137 co-stimulation in enabling the immune system to elimi-nate tumors has been documented in a wide plethora of murine tumor models including mastocytoma, sarcoma, colon carci- CD137 is a potent costimulatory receptor. Several agonistic anti‐CD137 antibodies are currently in clinical trials for tumor immunotherapy.